Related Experiment Video

Updated: Dec 20, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
08:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

3.2K

Battling COVID-19: using old weapons for a new enemy

Rohit Kumar1, Nitin Gupta2, Parul Kodan3

  • 11Department of Medicine, All India Institute of Medical Sciences, New Delhi, 110029 India.

Tropical Diseases, Travel Medicine and Vaccines
|May 27, 2020
PubMed

Insights

This review examines drugs for COVID-19, evaluating their effectiveness against SARS-CoV-2 and related viruses. It assesses drug repurposing potential for managing the pandemic, noting limited randomized controlled trials for many treatments.

Area of Science:

  • Virology
  • Infectious Diseases
  • Pharmacology

Background:

  • The COVID-19 pandemic necessitates urgent therapeutic strategies.
  • Many investigational treatments for COVID-19 lack rigorous clinical evaluation.
  • Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) poses a significant global health threat.

Purpose of the Study:

  • To review in-vitro and in-vivo efficacy of drugs against SARS-CoV-2.
  • To assess the effectiveness of these drugs against related coronaviruses like SARS and MERS.
  • To evaluate the potential for repurposing existing drugs in COVID-19 management.

Main Methods:

  • Systematic literature search for relevant studies.
  • Analysis of in-vitro antiviral activity data.
  • Evaluation of in-vivo preclinical and clinical data for efficacy and safety.

Main Results:

  • Summarized efficacy data for various drug candidates.
  • Identified drugs with promising activity against SARS-CoV-2 and related viruses.
  • Highlighted gaps in evidence, particularly from randomized controlled trials.

Conclusions:

  • Several drugs show potential for COVID-19 treatment based on in-vitro and in-vivo studies.
  • Drug repurposing is a viable strategy, but requires further clinical validation.
  • Robust clinical trials are essential to confirm the safety and efficacy of repurposed drugs for COVID-19.
Keywords:
HydroxychloroquineLopinavir/ritonavirNitazoxanideRemdisivirSARS-CoV-2Tocilizumab

More Related Videos

Swabbing the Urban Environment - A Pipeline for Sampling and Detection of SARS-CoV-2 From Environmental Reservoirs07:13

Swabbing the Urban Environment - A Pipeline for Sampling and Detection of SARS-CoV-2 From Environmental Reservoirs

Published on: April 9, 2021

4.5K
Contact-Free Co-Culture Model for the Study of Innate Immune Cell Activation During Respiratory Virus Infection07:36

Contact-Free Co-Culture Model for the Study of Innate Immune Cell Activation During Respiratory Virus Infection

Published on: February 28, 2021

3.3K

Related Concept Videos

Defense Mechanism Against Infection01:26

Defense Mechanism Against Infection

Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
9.0K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.5K
Infection01:20

Infection

When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
11.4K
Cross-reactivity00:42

Cross-reactivity

Overview
32.7K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.2K