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When Zoonotic Organisms Cross Over-Trueperella pyogenes Endocarditis Presenting as a Septic Embolic Stroke

Smit Deliwala1, Thulasi Beere1, Varun Samji1

  • 1Internal Medicine, Hurley Medical Center, Michigan State University, Flint, USA.

Cureus
|May 27, 2020
PubMed

Insights

A rare zoonotic bacteria, Trueperella pyogenes, caused infective endocarditis and septic embolic stroke in a US patient. This case highlights the underdiagnosis of Trueperella pyogenes infections, which primarily affect non-humans.

Area of Science:

  • Infectious Diseases
  • Bacteriology
  • Neurology

Background:

  • Infective endocarditis (IE) is a serious global health concern with diverse causative agents.
  • Trueperella pyogenes, a zoonotic bacterium, is rarely implicated in human IE.
  • Accurate identification of Trueperella species can be challenging due to taxonomic revisions and misidentification.

Observation:

  • A case of infective endocarditis caused by Trueperella pyogenes is reported in the United States.
  • This represents the first reported case of Trueperella pyogenes-associated endocarditis presenting as a stroke in the US.
  • The patient developed a septic embolic stroke secondary to the endocarditis.

Findings:

  • Trueperella pyogenes, typically a pathogen in non-human species, can cause severe human infections like IE and stroke.
  • This case underscores the potential for zoonotic transmission leading to critical human illness.
  • The rarity of this pathogen in human endocarditis suggests potential underdiagnosis.

Implications:

  • Increased awareness of Trueperella pyogenes as a potential human pathogen is warranted, especially in cases of IE with unclear etiology.
  • Improved diagnostic methods may be needed to accurately identify Trueperella species and prevent misdiagnosis.
  • This case contributes to the limited literature on Trueperella pyogenes infections in humans, aiding future clinical recognition and management.
Keywords:
actinomyces pyogenesarcanobacterium pyogenesembolic cvaembolic strokeendocarditisseptic embolit. pyogenestrueperellatrueperella pyogeneszoonotic

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