Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biofilms01:29

Biofilms

922
Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
922
Lytic Cycle of Bacteriophages01:30

Lytic Cycle of Bacteriophages

77.0K
Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the...
77.0K
DNA Bacteriophages01:26

DNA Bacteriophages

600
Bacteriophages, or phages, are viruses that specifically infect bacteria, utilizing their genetic material to hijack host cellular machinery for replication. DNA bacteriophages employ single-stranded DNA (ssDNA) or double-stranded DNA (dsDNA) genomes. These phages exhibit diverse replication strategies and host interactions, influencing their ecological roles and applications in biotechnology and medicine.ssDNA BacteriophagesssDNA phages, with their small genomes, utilize unique strategies to...
600
Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

702
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
702
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

390
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
390

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phenotypic heterogeneity shapes phage resistance and cocktail efficacy in <i>Klebsiella pneumoniae</i>.

Microbiology spectrum·2026
Same author

Phage-meropenem synergy against OXA-48-producing Klebsiella pneumoniae clinical isolates.

npj antimicrobials and resistance·2026
Same author

Effects of phage-based treatments against an OXA-48-producing Klebsiella pneumoniae isolate in simulated human gut microbiomes.

BMC microbiology·2026
Same author

The host range of generalist and specialist phages in capsule-diverse Klebsiella hosts is driven by the evolvability of receptor-binding proteins.

PLoS biology·2025
Same author

Resolution of acute rejection in a bilateral double-lung transplanted cystic fibrosis patient following phage intervention.

ASM case reports·2025
Same author

Unlocking data in Klebsiella lysogens to predict capsular type-specificity of phage depolymerases.

Nature communications·2025

Related Experiment Video

Updated: Dec 20, 2025

Author Spotlight: Efficiently Eliminating Bacteriophages from Infected Salmonella Cultures Using Lipopolysaccharides
07:19

Author Spotlight: Efficiently Eliminating Bacteriophages from Infected Salmonella Cultures Using Lipopolysaccharides

Published on: June 28, 2024

1.5K

Phages for Biofilm Removal.

Celia Ferriol-González1, Pilar Domingo-Calap1,2

  • 1Department of Genetics, Universitat de València, 46100 Valencia, Spain.

Antibiotics (Basel, Switzerland)
|May 28, 2020
PubMed
Summary

Bacterial biofilms pose significant threats, causing infections and economic losses. Phage-based treatments show promise for biofilm eradication, offering advantages and challenges for effective elimination.

Keywords:
antibiotic resistancebacteriophagebiofilmphage therapy

More Related Videos

Biofilm Removal Using Carbon Dioxide Aerosols without Nitrogen Purge
07:11

Biofilm Removal Using Carbon Dioxide Aerosols without Nitrogen Purge

Published on: November 6, 2016

6.7K
Evaluation of the Efficacy of Organic Peroxyacids for Eradicating Dairy Biofilms Using an Approach Combining Static and Dynamic Methods
11:47

Evaluation of the Efficacy of Organic Peroxyacids for Eradicating Dairy Biofilms Using an Approach Combining Static and Dynamic Methods

Published on: December 9, 2022

2.0K

Related Experiment Videos

Last Updated: Dec 20, 2025

Author Spotlight: Efficiently Eliminating Bacteriophages from Infected Salmonella Cultures Using Lipopolysaccharides
07:19

Author Spotlight: Efficiently Eliminating Bacteriophages from Infected Salmonella Cultures Using Lipopolysaccharides

Published on: June 28, 2024

1.5K
Biofilm Removal Using Carbon Dioxide Aerosols without Nitrogen Purge
07:11

Biofilm Removal Using Carbon Dioxide Aerosols without Nitrogen Purge

Published on: November 6, 2016

6.7K
Evaluation of the Efficacy of Organic Peroxyacids for Eradicating Dairy Biofilms Using an Approach Combining Static and Dynamic Methods
11:47

Evaluation of the Efficacy of Organic Peroxyacids for Eradicating Dairy Biofilms Using an Approach Combining Static and Dynamic Methods

Published on: December 9, 2022

2.0K

Area of Science:

  • Microbiology
  • Biotechnology

Background:

  • Biofilms are bacterial communities encased in an extracellular matrix, adhering to biotic and abiotic surfaces.
  • Biofilms cause significant infectious diseases and economic losses.
  • Conventional antibiotics and disinfectants are often ineffective against biofilms.

Purpose of the Study:

  • To review the advantages and challenges of using bacteriophages for biofilm eradication.
  • To identify key factors for designing effective phage-based biofilm treatments.

Main Methods:

  • Literature review of current research on biofilms and phage therapy.
  • Analysis of factors influencing phage efficacy in biofilm environments.

Main Results:

  • Phages offer a promising alternative to conventional treatments for biofilm removal.
  • Challenges include phage resistance, delivery, and specificity.
  • Effective treatment design requires consideration of phage characteristics and biofilm properties.

Conclusions:

  • Phage therapy presents a viable strategy for combating biofilm-related infections.
  • Further research is needed to optimize phage-based treatments for clinical application.