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Electrospun Orodispersible Films of Isoniazid for Pediatric Tuberculosis Treatment

Konstantina Chachlioutaki1, Emmanouil K Tzimtzimis2, Dimitrios Tzetzis2

  • 1Laboratory of Pharmaceutical Technology, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece.

Pharmaceutics
|May 28, 2020
PubMed

Insights

Researchers developed novel orodispersible films (ODFs) for pediatric isoniazid administration. These fast-dissolving films offer improved adherence for children undergoing tuberculosis treatment, especially in resource-limited areas.

Area of Science:

  • Pharmaceutical Technology
  • Pediatric Pharmacotherapy
  • Drug Delivery Systems

Background:

  • Child-appropriate dosage forms are crucial for treatment adherence in pediatric patients, particularly in low-resource settings.
  • Long-term treatments like tuberculosis therapy require effective and easy-to-administer medication options for children.

Purpose of the Study:

  • To develop and characterize orodispersible films (ODFs) for isoniazid administration to children exposed to tuberculosis.
  • To evaluate the physicochemical properties, disintegration, and drug release of the developed ODFs.

Main Methods:

  • Orodispersible films (ODFs) were fabricated using electrospinning of natural and semi-synthetic polymer blends.
  • Physicochemical characterization of spinning solutions and nanofibers was performed.
  • Disintegration time and isoniazid release kinetics were assessed in simulated salivary fluid.

Main Results:

  • The ODFs consisted of nanofibers exhibiting good thermal stability and potential drug amorphization.
  • Films disintegrated rapidly within 15 seconds in simulated salivary fluid.
  • Complete isoniazid release was achieved within 60 seconds post-disintegration.

Conclusions:

  • The developed isoniazid ODFs are a promising, easy-to-administer dosage form for pediatric tuberculosis treatment.
  • These ODFs demonstrate favorable drug release profiles, potentially enhancing patient adherence.
  • This novel dosage form could significantly improve pharmacotherapy outcomes in pediatric populations.

Keywords:
electrospinningisoniazidorodispersible filmspediatric drug deliverytuberculosis

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