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A Guide to the Short, Long and Circular RNAs in Hypertension and Cardiovascular Disease

Priscilla R Prestes1, Michelle C Maier1, Bradley A Woods1

  • 1School of Health and Life Sciences, Federation University Australia, Ballarat, VIC 3350, Australia.

International Journal of Molecular Sciences
|May 28, 2020
PubMed

Insights

Circular RNAs (circRNAs) show promise as biomarkers and therapeutic targets for cardiovascular diseases (CVD), particularly hypertension. These non-coding RNAs offer new avenues for diagnosing and treating conditions like hypertension.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cardiology

Background:

  • Cardiovascular disease (CVD) is a major cause of death globally, encompassing conditions like hypertension and atherosclerosis.
  • Non-coding RNAs, including circular RNAs (circRNAs), play a role in gene regulation and are implicated in CVD.
  • CircRNAs, formed by pre-messenger RNA back-splicing, are increasingly recognized for their involvement in cardiovascular processes.

Purpose of the Study:

  • To review the emerging roles of circRNAs in cardiovascular disease (CVD).
  • To explore the potential of circRNAs as biomarkers for CVD, including hypertension.
  • To discuss circRNAs as potential therapeutic targets for CVD.

Main Methods:

  • Literature review of studies on non-coding RNAs and cardiovascular disease.
  • Focus on circular RNAs (circRNAs) and their biogenesis.
  • Analysis of circRNAs' involvement in hypertension and other CVDs.

Main Results:

  • CircRNAs are implicated in various cardiovascular disease processes, including hypertension.
  • CircRNAs can be detected in accessible bodily fluids, suggesting biomarker potential.
  • Emerging evidence highlights circRNAs' roles in CVD pathogenesis.

Conclusions:

  • Circular RNAs (circRNAs) represent a promising area for CVD biomarker discovery.
  • CircRNAs may offer novel therapeutic strategies for cardiovascular diseases, especially hypertension.
  • Further research into circRNAs is crucial for advancing CVD diagnosis and treatment.

Keywords:
atherosclerosiscardiovascular diseasecircular RNAcoronary artery diseaseheart diseasehypertensionlong non-coding RNAmicroRNA

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