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Overview Of Cell Separation And Isolation01:20

Overview Of Cell Separation And Isolation

Cell separation was first achieved in 1964 by S. H. Seal, who separated large tumor cells from the smaller blood cells using filtration. Two years later, Pohl and Hawk performed experiments on how cells respond differently to a nonuniform electric field based on the cell type. Such observations were the inception of cell separation methods, which allow isolating a single cell type from a heterogeneous sample.

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Related Experiment Video

Updated: Jul 5, 2026

Rapid Isolation of Viable Circulating Tumor Cells from Patient Blood Samples
07:32

Rapid Isolation of Viable Circulating Tumor Cells from Patient Blood Samples

Published on: June 15, 2012

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A Review on Microdevices for Isolating Circulating Tumor Cells.

Kin Fong Lei1,2

  • 1Graduate Institute of Biomedical Engineering, Chang Gung University, Taoyuan 333, Taiwan.

Micromachines
|May 28, 2020
PubMed
Summary

Circulating tumor cell (CTC) isolation technologies in microdevices are crucial for predicting cancer patient outcomes. Recent advancements offer promising methods for precise therapeutic evaluation in metastatic cancers.

Keywords:
CTC isolationcancer metastasiscirculating tumor cellsmicrodevices

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Last Updated: Jul 5, 2026

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Area of Science:

  • Oncology
  • Biomedical Engineering
  • Translational Medicine

Background:

  • Cancer metastasis is a leading cause of cancer-related mortality.
  • Enumerating circulating tumor cells (CTCs) aids in predicting therapeutic outcomes for metastatic cancers.
  • Microdevice technologies are advancing for CTC isolation.

Purpose of the Study:

  • To review recent developments in microdevice-based CTC isolation technologies.
  • To discuss biochemical and biophysical isolation approaches.
  • To provide an overview of the current challenges and advancements in CTC isolation.

Main Methods:

  • Literature review of recent studies on CTC isolation technologies.
  • Categorization of isolation methods into biochemical and biophysical approaches.
  • In-depth discussion of the reviewed technologies.

Main Results:

  • Significant progress has been made in microdevice-based CTC isolation.
  • Both biochemical and biophysical methods show promise for CTC enrichment.
  • Current technologies are moving towards precise and reliable CTC enumeration.

Conclusions:

  • Advanced CTC isolation technologies in microdevices are vital for cancer management.
  • These methods offer a promising avenue for developing precise indicators of therapeutic outcomes.
  • Further development is expected to enhance the clinical utility of CTC analysis.