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Regulation of Src Family Kinases during Colorectal Cancer Development and Its Clinical Implications

Wook Jin1

  • 1Laboratory of Molecular Disease and Cell Regulation, Department of Biochemistry, School of Medicine, Gachon University, Incheon 406-840, Korea.

Cancers
|May 28, 2020
PubMed

Insights

Src family kinases (SFKs) are crucial in colorectal cancer (CRC) development, promoting proliferation, metastasis, and chemoresistance. Targeting SFKs offers potential therapeutic strategies for CRC patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Src family kinases (SFKs) are implicated in colorectal cancer (CRC) pathogenesis.
  • Elevated SFK expression and activity are observed in CRC patients.
  • SFKs contribute to CRC cell proliferation, metastasis, chemoresistance, and cancer stem cell (CSC) formation.

Purpose of the Study:

  • To review the role of SFKs in CRC progression.
  • To focus on SFK involvement in proliferation, invasion, metastasis, chemoresistance, and CSCs.
  • To discuss therapeutic strategies targeting SFKs in CRC.

Main Methods:

  • Literature review of studies on SFKs and CRC.
  • Analysis of SFK-mediated signaling pathways in CRC.
  • Examination of preclinical and clinical data on SFK inhibitors.

Main Results:

  • SFK activation drives key aspects of CRC progression.
  • SFK expression levels correlate with patient survival.
  • SFKs regulate CRC through interactions with various cellular components.

Conclusions:

  • SFKs are significant drivers of colorectal cancer.
  • Targeting SFKs presents a promising therapeutic avenue for CRC.
  • Further research into SFK inhibitors can improve CRC treatment efficacy.
Keywords:
Src family kinasescancer stem cellscolorectal cancerdrug targetingepithelial–mesenchymal transitionmetastasis

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