Related Experiment Video

Updated: Dec 20, 2025

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

14.2K

Hemostatic laboratory derangements in COVID-19 with a focus on platelet count

Ariunzaya Amgalan1, Maha Othman2,3

  • 1School of Medicine, Georgetown University , Washington, DC, USA.

Platelets
|May 28, 2020
PubMed

Insights

Investigating coronavirus disease 2019 (COVID-19) coagulopathies, this report focuses on platelet count alterations. Thrombocytopenia may serve as a potential biomarker for COVID-19 severity and mortality.

Area of Science:

  • Hematology
  • Virology
  • Immunology

Background:

  • COVID-19, caused by SARS-CoV-2, has led to a global pandemic with significant mortality.
  • Coagulopathies, including DIC, VTE, and thrombo-inflammation, are frequently observed in COVID-19 patients.
  • Existing research presents conflicting data on hematological derangements and their correlation with COVID-19 progression and outcomes.

Purpose of the Study:

  • To examine published evidence on hematological and hemostatic derangements in COVID-19.
  • To discuss the relationship between SARS-CoV-2 infection, inflammation, and platelet count alterations.
  • To evaluate thrombocytopenia as a potential predictive biomarker for COVID-19 severity and mortality.

Main Methods:

  • Review of existing literature on COVID-19 associated coagulopathies and hematological changes.
  • Focused analysis of studies investigating platelet count alterations in COVID-19.
  • Exploration of the link between thrombocytopenia, inflammation, and disease outcomes.

Main Results:

  • COVID-19 is associated with a range of coagulopathies and hematological abnormalities.
  • Evidence suggests a correlation between thrombocytopenia and increased COVID-19 severity or mortality.
  • SARS-CoV-2 infection triggers inflammatory responses that impact hemostasis and platelet counts.

Conclusions:

  • Thrombocytopenia is a notable hematological finding in COVID-19.
  • Further research is warranted to validate thrombocytopenia as a reliable biomarker for predicting COVID-19 progression and outcomes.
  • Understanding these hematological derangements is crucial for managing COVID-19 patients.

Keywords:
COVIDSARS-CoV-2plateletsthrombocytopeniathromboinflammation

More Related Videos

Microfluidics in Assessing Platelet Function06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.4K
Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

1.0K

Related Concept Videos

Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
8.4K
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
1.8K
Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
2.6K
Introduction to Hemostasis01:05

Introduction to Hemostasis

Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
12.6K
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.4K