[CME: Endogenous Hypercortisolism (Endogenous Cushing's Syndrome)].

Area of Science:

• Endocrinology
• Internal Medicine

Background:

• Endogenous Cushing's syndrome (eCS) is a rare endocrine disorder.
• Early symptoms of eCS are often non-specific, delaying diagnosis.
• Untreated eCS leads to significant morbidity and mortality.

Purpose of the Study:

• To provide an overview of the etiology of eCS.
• To describe the clinical presentation of eCS.
• To outline diagnostic strategies for eCS, focusing on screening tests.

Main Methods:

• Literature review of endogenous hypercortisolism.
• Analysis of clinical manifestations.
• Evaluation of diagnostic screening tests for eCS.

Main Results:

• eCS etiology varies, leading to excess cortisol production.
• Clinical signs and symptoms can be subtle initially.
• Specific screening tests aid in early eCS detection.

Conclusions:

• Prompt diagnosis of eCS is essential for patient outcomes.
• Understanding etiology and presentation improves diagnostic accuracy.
• Targeted screening tests are vital for managing eCS.