Lipid profile and left ventricular geometry pattern in obese children.

Area of Science:

• Pediatric Cardiology
• Cardiovascular Research
• Metabolic Syndrome

Background:

• Left ventricular hypertrophy (LVH) is a significant risk factor for mortality.
• Conflicting data exist on the association between serum lipids and LVH patterns.
• The relationship between lipid profiles and LVH in obese children requires further investigation.

Purpose of the Study:

• To investigate the association between standard serum lipid profile measures and left ventricular geometry patterns in obese children.
• To explore the link between lipid ratios, BMI, blood pressure, and LVH in pediatric obesity.

Main Methods:

• Cross-sectional study of 70 obese children.
• Measurement of serum lipids (total cholesterol, LDL-C, HDL-C, triglycerides), glucose, and insulin.
• Calculation of TG/HDL ratio, BMI, and HOMA index.
• Assessment of 24-h ambulatory systolic blood pressure and echocardiography for LVMI and RWT.

Main Results:

• A positive association was found between TG/HDL ratio, BMI, and 24-h SBP with LVMI.
• Increased BMI and insulin levels were significantly associated with RWT.
• The TG/HDL ratio was linked to eccentric LVH, while BMI and insulin were linked to concentric LVH.

Conclusions:

• Elevated TG/HDL ratio in obese children correlates with eccentric LVH development.
• Increased BMI and insulin levels are associated with concentric LVH in this population.
• These findings highlight the importance of lipid profiles and metabolic markers in pediatric obesity-related cardiac remodeling.