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Cardiovascular disease potentially contributes to the progression and poor prognosis of COVID-19

Mingyue Li1, Yalan Dong1, Haijun Wang2

  • 1Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|May 28, 2020
PubMed

Insights

Cardiovascular disease (CVD) significantly worsens COVID-19 outcomes. Patients with CVD experienced more severe lung damage, inflammation, and higher mortality, highlighting the need for intensive care.

Area of Science:

  • Infectious Diseases
  • Cardiology
  • Pulmonology

Background:

  • COVID-19, caused by SARS-CoV-2, presents varied patient outcomes.
  • Comorbidities are suspected to influence COVID-19 progression and prognosis.
  • The specific role of cardiovascular disease (CVD) in COVID-19 requires further investigation.

Purpose of the Study:

  • To investigate the impact of cardiovascular disease (CVD) on the progression and prognosis of COVID-19 patients.
  • To compare clinical characteristics and outcomes between COVID-19 patients with and without CVD.

Main Methods:

  • Retrospective analysis of 83 confirmed COVID-19 patients.
  • Patients categorized into CVD (n=42) and non-CVD (n=41) groups.
  • Comparison of demographic data, medical history, clinical features, lab results, chest CT, and treatments.

Main Results:

  • COVID-19 patients with CVD exhibited more severe lung pathology.
  • Elevated injury markers (HDBH, LDH, GGT, CK, ALT) were observed in the CVD group.
  • Increased inflammation markers (CRP, IL-6, ferritin, ESR, SAA), hypercoagulable status (D-dimer, FIB), and higher mortality were noted in COVID-19 patients with CVD.

Conclusions:

  • Cardiovascular disease (CVD) is identified as a significant risk factor for rapid COVID-19 progression.
  • CVD is associated with a poorer prognosis in COVID-19 patients.
  • Intensified medical care is recommended for COVID-19 patients with CVD to prevent severe deterioration.
Abstract

Keywords:
COVID-19Cardiovascular diseasePrognosis

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