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Decrease in antimicrobial susceptibility of Bordetella bronchiseptica caused by antigenic modulation and phase

H Ishikawa1, Y Isayama, K Ohmae

  • 1Hokkaido Research Station, National Institute of Animal Health, Sapporo, Japan.

Antimicrobial Agents and Chemotherapy
|December 1, 1988
PubMed
Summary
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Bordetella bronchiseptica variants showed increased resistance to several antimicrobial agents compared to their parent strains. This suggests potential challenges in treating infections caused by these bacterial variants.

Area of Science:

  • Microbiology
  • Bacterial genetics
  • Antimicrobial resistance

Background:

  • Bordetella bronchiseptica is a bacterium that can cause respiratory infections.
  • Bacterial variants can emerge with altered characteristics, potentially affecting treatment efficacy.
  • Understanding antimicrobial susceptibility is crucial for effective disease management.

Purpose of the Study:

  • To compare the antimicrobial susceptibility of Bordetella bronchiseptica variants in C mode and degraded phases with their parent strains in X mode.
  • To identify specific antimicrobial agents to which these variants exhibit altered resistance.

Main Methods:

  • Comparative analysis of bacterial strains: variants versus parent strains.
  • Evaluation of susceptibility to 20 different antimicrobial agents.

Related Experiment Videos

  • Determination of Minimum Inhibitory Concentrations (MICs) to quantify resistance levels.

    • Main Results:

    • Variants in C mode and degraded phases displayed significantly increased Minimum Inhibitory Concentrations (MICs) compared to parent strains.
    • Observed fold-increases in MICs ranged from 4- to 32-fold for specific antibiotics.
    • Antibiotics showing increased resistance included ampicillin, carbenicillin, erythromycin, novobiocin, rifampin, chloramphenicol, nalidixic acid, and oxolinic acid.

    Conclusions:

    • Bordetella bronchiseptica variants exhibit reduced susceptibility to a range of common antimicrobial agents.
    • The observed resistance patterns may impact the clinical management of infections caused by these variants.
    • Further research is warranted to understand the mechanisms of resistance and guide therapeutic strategies.