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Updated: Dec 20, 2025
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Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
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Circular RNA in Schizophrenia and Depression
Zexuan Li1,2, Sha Liu1,2, Xinrong Li1,2
1Shanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, China.
Frontiers in Psychiatry
|May 28, 2020
Summary
Circular RNAs (circRNAs) show potential as objective biomarkers for diagnosing schizophrenia and depression. These non-coding RNAs are stable, detectable in blood, and may improve early detection and prognosis of these psychiatric disorders.
Area of Science:
- Biochemistry
- Genetics
- Psychiatry
Background:
- Schizophrenia (SZ) and depression (DEP) are major psychiatric disorders linked to suicide risk.
- Current diagnostic methods rely on subjective symptoms, leading to potential misdiagnoses.
- Objective biomarkers are needed for improved early diagnosis and prognosis of SZ and DEP.
Purpose of the Study:
- To review the classification, characteristics, and functions of circular RNAs (circRNAs).
- To highlight the role of circRNAs in the development of SZ and DEP.
- To explore the diagnostic and therapeutic potential of circRNAs in psychiatric disorders.
Main Methods:
- Literature review of circRNA research in SZ and DEP.
- Summary of circRNA classification, characteristics, and biological functions.
- Analysis of experimental studies on circRNA involvement in psychiatric disorders.
Main Results:
- Circular RNAs (circRNAs) are a class of non-coding RNAs involved in post-transcriptional regulation.
- circRNAs are stable, tissue-specific, and detectable in peripheral blood.
- Emerging evidence suggests circRNAs play a role in the pathophysiology of SZ and DEP.
Conclusions:
- circRNAs hold promise as objective biomarkers for SZ and DEP.
- Their detectability in blood offers a minimally invasive approach for diagnosis.
- Further research into circRNAs could lead to novel diagnostic and therapeutic strategies for psychiatric disorders.
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