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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

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Irritable Bowel Syndrome I: Introduction01:17

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Bladder bowel dysfunction in children with Down's syndrome.

Nikita R Bhatt1, Louise Murchison2, George Yardy3

  • 1Department of Urology, Ipswich Hospital, East Suffolk and North Essex NHS Foundation Trust (ESNEFT), Heath Rd, Ipswich, IP4 5PD, UK. nikitarb89@gmail.com.

Pediatric Surgery International
|May 28, 2020
PubMed
Summary
This summary is machine-generated.

Bladder Bowel Dysfunction (BBD) is common in Down's Syndrome (DS) and often requires surgery. Early identification and management are crucial for protecting the renal tract in these patients.

Keywords:
Lower urinary tract symptomsNeurogenic bladderNon-neurogenicTrisomy 21Voiding dysfunction

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Area of Science:

  • Pediatric Urology
  • Genetics
  • Gastroenterology

Background:

  • Bladder Bowel Dysfunction (BBD) is a recognized condition in individuals with Down's Syndrome (DS).
  • Understanding the specific challenges faced by DS patients with BBD is essential for effective care.

Purpose of the Study:

  • To determine the incidence, demographics, presentation, complications, and bladder management strategies in Down's Syndrome patients experiencing Bladder Bowel Dysfunction.
  • To consolidate the largest available cohort of BBD cases in DS patients.

Main Methods:

  • A systematic review adhering to PRISMA guidelines was conducted.
  • Searches were performed on MEDLINE and SCOPUS using specific keywords related to Down's Syndrome and voiding dysfunction.
  • A case series from two pediatric urology centers was incorporated.

Main Results:

  • The study included 38 patients with BBD and DS, with a mean age of 12 years and a 2:1 male:female ratio.
  • Common presentations included functional constipation (90%), recurrent urinary tract infections (38%), and enuresis (56%).
  • Over 56% of patients required surgical intervention, with medical and behavioral treatments showing limited success.

Conclusions:

  • BBD is prevalent in DS patients and can lead to severe complications necessitating surgical intervention.
  • Standard interventions are often unreliable due to poor patient compliance.
  • Early identification and management are vital for renal tract protection; regular screening for urogenital anomalies in DS is recommended.