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Updated: Dec 20, 2025

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A Protocol for the Administration of Real-Time fMRI Neurofeedback Training
Published on: August 24, 2017
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EEG Theta/Beta Ratio Neurofeedback Training in Healthy Females
Dana van Son1,2, Willem van der Does3,4, Guido P H Band3,4
1Institute of Psychology, Leiden University, Leiden, The Netherlands. dana.vanson@yale.edu.
Applied Psychophysiology and Biofeedback
|May 28, 2020
Summary
Neurofeedback training targeting the electroencephalogram theta/beta ratio (TBR) did not reduce TBR in healthy adults. Current protocols for TBR neurofeedback training may be ineffective for enhancing cognitive control.
Area of Science:
- Neuroscience
- Cognitive Psychology
- Biofeedback
Background:
- The electroencephalogram (EEG) theta/beta ratio (TBR) is increasingly linked to executive cognitive control.
- Neurofeedback training (NFT) targeting TBR reduction (TBR NFT) is proposed as a method to investigate this relationship and potentially improve cognitive performance.
Purpose of the Study:
- To determine if TBR NFT effectively reduces TBR in healthy individuals.
Main Methods:
- Twelve healthy female participants were enrolled in a single-blind study.
- Participants were divided into three groups: two receiving TBR NFT for eight or fourteen sessions, and one receiving sham NFT.
- Sessions were 25 minutes long.
Main Results:
- No significant evidence was found to support that TBR NFT reduced the TBR.
- The results suggest the current TBR NFT protocol may be ineffective.
Conclusions:
- The study failed to demonstrate the efficacy of the employed TBR NFT protocol in reducing TBR.
- Findings align with previous research suggesting potential ineffectiveness of current TBR NFT protocols, warranting further investigation into protocol optimization.

