Related Experiment Video

Updated: Dec 20, 2025

A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice
06:27

A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice

Published on: July 20, 2022

3.0K

A case of suspected antibiotic-associated encephalopathy in a patient undergoing long-term peritoneal dialysis

Yibin Guo1, Xiaojiao Shao1, Liyuan Zhang1

  • 1Department of Nephrology, Lianyungang No 1 People's Hospital, Jiangsu, China.

The Journal of International Medical Research
|May 28, 2020
PubMed

Insights

Clindamycin treatment for pulmonary infection in a patient on peritoneal dialysis led to psychosis and auditory hallucinations. Symptoms resolved after discontinuing the antibiotic, suggesting a potential link to antibiotic-related encephalopathy.

Area of Science:

  • Nephrology
  • Neurology
  • Infectious Diseases

Background:

  • Peritoneal dialysis (PD) is a crucial treatment for end-stage renal disease (ESRD).
  • Antibiotic use in ESRD patients requires careful consideration due to altered drug metabolism and excretion.

Observation:

  • A patient on long-term PD developed acute psychosis and auditory hallucinations.
  • These neurological symptoms emerged two days after initiating clindamycin for a pulmonary infection.

Findings:

  • Discontinuation of clindamycin and enhanced PD led to the complete resolution of psychotic symptoms.
  • Electroencephalogram (EEG) showed a slow rhythm, while head and chest CT scans were unremarkable.

Implications:

  • Clindamycin may induce antibiotic-related encephalopathy, particularly in patients with impaired renal function.
  • Clinicians must exercise caution when prescribing antibiotics to ESRD patients, monitoring for potential neurological side effects.
Keywords:
Encephalopathyantibiotic-related encephalopathyclindamycinend-stage renal diseaseperitoneal dialysispsychosis

More Related Videos

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis07:11

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis

Published on: July 19, 2018

15.8K
A Mice Model of Chlorhexidine Gluconate-Induced Peritoneal Damage04:25

A Mice Model of Chlorhexidine Gluconate-Induced Peritoneal Damage

Published on: April 28, 2022

2.1K

Related Concept Videos

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications01:25

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
327
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
204
Peritoneal Dialysis III: Nursing Management01:25

Peritoneal Dialysis III: Nursing Management

Peritoneal dialysis, or PD, utilizes the peritoneal membrane as a filter to eliminate excess fluid and waste products. Effective nursing management is essential for ensuring patient safety, preventing complications, and promoting optimal function of the peritoneal dialysis process.Assessment and MonitoringNurses must thoroughly assess the patient before, during, and after each dialysis session. Regular monitoring includes vital signs, daily weight, fluid intake and output, and laboratory values...
484
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
205
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
265
Peritoneal Dialysis I: Introduction and Procedure01:30

Peritoneal Dialysis I: Introduction and Procedure

Peritoneal dialysis (PD) is a procedure that facilitates the exchange of solutes, waste products, electrolytes, and excess fluid between the blood in the peritoneal capillaries and a dialysis solution introduced into the peritoneal cavity.Principles of Peritoneal Dialysis (PD)Diffusion: Waste products such as urea and electrolytes move from high concentrations in the blood to low concentrations in the dialysate across the peritoneal membrane. This mechanism is driven by the concentration...
1.6K