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Updated: Dec 20, 2025

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging
Published on: April 28, 2021
Buformin increases radiosensitivity in cervical cancer cells via cell-cycle arrest and delayed DNA-damage repair
Ling Chen1,2, Ting Zhang1,2, Qiuli Liu2
1Department of Gynecology, Affiliated Hospital of Jiangnan University, Wuxi 214062, China.
Impact Statement:
Our idea originated in the thought of discovering new effects of old drugs. Although this study is a basic research, it is very close to clinical treatment. Flow cytometry and immunofluorescence were used to verify that buformin increases radiosensitivity. We aimed to address one of the thorniest problems in treatment process. Based on discovering new effects of old drugs, it is feasible to use buformin as an anticancer drug in clinical application. This will provide new ideas for clinical treatment.
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