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Genetic Screens

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...

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Updated: Dec 20, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

How to Transition from Single-Gene Pharmacogenetic Testing to Preemptive Panel-Based Testing: A Tutorial.

Richard J Marrero¹, Emily J Cicali^1,2, Meghan J Arwood^1,2

¹Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, Florida, USA.

Clinical Pharmacology and Therapeutics

|May 28, 2020

Summary

This summary is machine-generated.

Precision medicine advances pharmacogenetic testing. The University of Florida Health Precision Medicine Program (PMP) transitioned from single-gene to panel-based testing for tailored drug regimens, improving patient care.

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Published on: April 11, 2016

Area of Science:

Pharmacogenomics
Clinical Pharmacology
Genomic Medicine

Background:

Growing patient demand for personalized medicine driven by direct-to-consumer genetic testing.
Increasing awareness of genetic variability influencing drug response.
Need for improved integration of genomic data into clinical practice.

Purpose of the Study:

To provide guidance on transitioning from single-gene to panel-based pharmacogenetic testing.
To demonstrate the application of a preemptive panel-based approach in an adult oncology clinic.
To facilitate the adoption of panel-based pharmacogenetics in diverse clinical settings.

Main Methods:

Implementation of a custom-designed pharmacogenetic panel (GatorPGx) at UF Health.
Focus on pharmacogenes relevant to supportive care medications in chemotherapy.
Demonstration in an adult solid tumor oncology clinic setting.

Main Results:

Successful implementation of single-gene pharmacogenetic tests.
Launch of a comprehensive, preemptive panel-based pharmacogenetic testing approach.
Demonstrated utility of the GatorPGx panel in optimizing medication selection.

Conclusions:

Panel-based pharmacogenetic testing offers a scalable approach to precision medicine.
The GatorPGx panel can enhance supportive care for oncology patients.
Guidance provided is applicable to various clinical practice settings for broader adoption.