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Related Experiment Video

Updated: Dec 20, 2025

Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection
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Viral Infections in Burns.

John L Kiley1, Kevin K Chung2, Dana M Blyth3

  • 1Brooke Army Medical Center, Fort Sam Houston, Texas, USA.

Surgical Infections
|May 29, 2020
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Summary

Viral infections, primarily herpesviruses, can complicate severe burn injuries, leading to poor outcomes. Early recognition and antiviral therapy are crucial, but more research is needed for optimal management.

Keywords:
SARTs-Co-V-2 virusantiviral drugsburnscytomegalovirusherpes simplex virushuman immunodeficiency virusvaricella zoster virus

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Area of Science:

  • Burn care and infectious diseases
  • Virology and immunology

Background:

  • Viral infections are less common than bacterial infections in burn patients but are associated with severe injuries and poor outcomes.
  • Herpesviruses (HSV, VZV, CMV, HHV-6) are the most common viral pathogens, often presenting as reactivation of latent infections.
  • Other viral infections like HIV, Hepatitis B/C, and SARS-CoV-2 can also complicate burn patient management.

Purpose of the Study:

  • To provide an overview of the management of viral infections in burn patients.
  • To highlight the challenges in diagnosing and treating viral infections due to limited data in this population.
  • To emphasize the need for further research into viral infection risks and outcomes in burn care.

Main Methods:

  • Retrospective reviews and case series were examined.
  • Literature review focusing on viral infections in burn patients.
  • Extrapolation of treatment evidence from critically ill and immunosuppressed non-burn populations.

Main Results:

  • Herpesviruses are the most frequent viral culprits, commonly reactivating from latency.
  • Treatment strategies often rely on antiviral therapy, extrapolated from other patient groups.
  • Data on viral infections in burn patients is limited, impacting evidence-based treatment protocols.

Conclusions:

  • Major burn injuries can lead to immunosuppression, increasing the risk of viral infections.
  • Prompt recognition and antiviral treatment are essential for managing viral infections in burn patients.
  • Further research is critical to understand the specific risks, clinical presentations, and impact of viral infections on burn patient outcomes.