Clinical manifestations and associated disorders in children with celiac disease in southern Iran
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Mahshid Dehbozorgi1, Naser Honar2, Maryam Ekramzadeh1
1Shiraz University of Medical Sciences, Shiraz, Iran.
Insights
Pediatric celiac disease (CD) presents with varied symptoms, including gastrointestinal issues like abdominal pain and constipation, and extra-intestinal signs such as bone pain and fatigue. Common comorbidities include type 1 diabetes and hypothyroidism.
Area of Science:
- Pediatric Gastroenterology
- Immunology
- Genetics
Background:
- Celiac disease (CD) is an immune-mediated enteropathy triggered by gluten in genetically predisposed individuals (HLA-DQ2/DQ8).
- Pediatric celiac disease presentation is evolving, with a rise in non-classical symptoms.
- This study focuses on evaluating the diverse clinical manifestations of diagnosed pediatric celiac disease.
Purpose of the Study:
- To investigate the clinical presentations of celiac disease in children.
- To identify common gastrointestinal and extra-intestinal symptoms.
- To determine associated comorbidities in pediatric celiac disease patients.
Main Methods:
- A cross-sectional study involving 130 pediatric celiac patients.
- Data collected via hospital charts and interviews with patients and parents.
- Analysis included demographic data, symptoms, laboratory findings, and Marsh grading for histopathology.
Main Results:
- Celiac disease was more prevalent in females (63.8%).
- Common gastrointestinal symptoms included abdominal pain, flatulence, and constipation.
- Frequent extra-intestinal manifestations were bone pain, fatigue, and anemia; type 1 diabetes and hypothyroidism were the most common comorbidities.
Conclusions:
- Pediatric celiac disease exhibits a range of gastrointestinal and extra-intestinal symptoms.
- Abdominal pain, flatulence, constipation, bone pain, fatigue, and anemia are key indicators.
- Type 1 diabetes mellitus and hypothyroidism are significant associated comorbidities in children with celiac disease.
Background:
Celiac disease (CD) is an immune mediated inflammatory enteropathy, triggered by gluten exposure in HLA-DQ2 and/or -DQ8 genetics. The presentation of celiac disease in children is changing, with increase in non-classical symptoms. We aim to evaluate the clinical presentations of celiac disease amongst children, diagnosed with CD.
Methods:
In this cross sectional study, we investigated the clinical features of 130 celiac patients at hospitals affiliated with Shiraz University of Medical Sciences. We used their hospital charts and conducted an interview with patients and their parents to find out demographic data, symptoms, laboratory, and histopathology findings for Marsh grading.
Results:
Celiac disease was detected more amongst females (63.8%). We found that 5.4% of the patients had BMI more than 95th percentile. The most common GI symptoms were abdominal pain, flatulence and constipation. Also, the most common extra intestinal manifestation included bone pain, long term fatigue and anemia. Flatulence, chronic diarrhea, and paresthesia were observed more amongst male participants. The most common comorbidities were type 1 diabetes mellitus and hypothyroidism.
Conclusion:
The most common gastrointestinal symptoms amongst our patients were abdominal pain, flatulence and constipation. Furthermore, the most common extra intestinal manifestations included bone pain, long term fatigue and anemia. The most associated comorbidities with CD in our children were type 1 diabetes mellitus and hypothyroidism.
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