Related Experiment Video
Updated: Dec 20, 2025

Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine
Published on: January 30, 2020
Hypoglycemic cardiac arrest and rapid return-of-spontaneous circulation (ROSC) with dextrose
Joan Rui Shan Fun1, Michael Yih Chong Chia1
1Department of Emergency Medicine, Tan Tock Seng Hospital, Singapore.
Insights
Hypoglycemia, a reversible cause of cardiac arrest, was previously in ACLS guidelines. This case highlights its importance in cardiac arrest patients, even if routine dextrose use is cautioned against.
Area of Science:
- Emergency Medicine
- Cardiology
- Critical Care Medicine
Background:
- Hypoglycemia was historically recognized as a reversible cause of cardiac arrest in ACLS guidelines.
- Current guidelines do not routinely recommend dextrose administration for undifferentiated cardiac arrest due to potential harm.
Observation:
- A case of return of spontaneous circulation following dextrose administration for confirmed hypoglycemia in a cardiac arrest patient is presented.
- This observation challenges the blanket exclusion of hypoglycemia management in cardiac arrest scenarios.
Findings:
- The patient achieved return of spontaneous circulation after dextrose was administered to correct documented hypoglycemia.
- This suggests that in specific cases, addressing hypoglycemia can be crucial for resuscitation outcomes.
Implications:
- Clinicians should maintain a high index of suspicion for hypoglycemia in cardiac arrest patients.
- Targeted glucose level assessment and correction in cardiac arrest may be warranted in select cases, despite general guidelines against routine dextrose use.
Abstract:
Hypoglycemia was part of the "H's and T's" in the 2005 American Heart Association ACLS guidelines for reversible causes of cardiac arrest but was removed in subsequent editions. We present a case of return of spontaneous circulation in a patient with cardiac arrest after administration of dextrose for hypoglycemia. Routine administration of dextrose to patients in cardiac arrest has been shown to be associated with increased mortality and worse neurological outcomes. However, this case reminds the clinician to consider hypoglycemia in patients with cardiac arrest, and to attempt correcting a low blood glucose if noted.
Related Concept Videos
Hypoglycemia and Glucagon
Cardiopulmonary Resuscitation IV: Pharmacological Management
SBAR II: Application of SBAR
SBAR Report from a Nurse to a Health Care Provider
S: "Hello, Dr. Smith. This is Jane, RN, from the Med Surg unit. I am calling to tell you about Ms. White in Room 210, who is experiencing increased pain and redness at her incision site. Her recent...
Cardiopulmonary Resuscitation I: Adult
Introduction Cardiac Emergencies
Cardiopulmonary Resuscitation III: AED Use

