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Non-osseous bone scan abnormalities in multiple myeloma associated with hypercalcemia
Clinical Nuclear Medicine
|December 1, 1988
Summary
Extraskeletal uptake of Tc-99m MDP during bone scans is rare but can indicate hypercalcemia in multiple myeloma patients. This finding suggests metastatic calcification in organs like the liver, spleen, and lungs.
Area of Science:
- Nuclear Medicine
- Nephrology
- Oncology
Background:
- Technetium-99m methylene diphosphonate (Tc-99m MDP) bone scintigraphy is primarily used for skeletal imaging.
- Extraskeletal uptake of Tc-99m MDP is an uncommon finding, often observed incidentally.
Observation:
- The study reports a rare case of Tc-99m MDP uptake in the liver, spleen, and lungs.
- This uptake occurred in a patient with hypercalcemia secondary to multiple myeloma and renal failure.
Findings:
- Non-osseous Tc-99m MDP uptake is hypothesized to represent metastatic calcification, requiring a critical calcium-phosphate ion product.
- Histological examination supports the presence of calcification in soft tissues.
Implications:
- While not diagnostic for multiple myeloma, extraskeletal Tc-99m MDP uptake can signify severe secondary effects of the disease, particularly hypercalcemia.
- This finding highlights the importance of correlating scintigraphic results with clinical data, including calcium levels and renal function.