Fluorescence Imaging Using Indocyanine Green Dye in the Pediatric Population

Area of Science:

• Surgical Imaging
• Pediatric Anesthesiology
• Medical Device Safety

Background:

• Indocyanine green (ICG) enables intraoperative vascular mapping.
• While generally safe, rare anaphylactoid reactions to ICG have been documented.

Purpose of the Study:

• To retrospectively review the safety and efficacy of intraoperative ICG administration in pediatric patients.
• To assess potential adverse respiratory or hemodynamic effects associated with ICG use in this population.

Main Methods:

• Retrospective review of anesthetic records for 100 pediatric patients over a 2-year period.
• Data collected included demographics, surgical details, and medication information.
• Intraoperative physiological parameters (heart rate, blood pressure, oxygen saturation, peak inflating pressure) were recorded before and after ICG administration.

Main Results:

• The cohort included 100 pediatric patients with a median age of 12 years.
• ICG was administered intravenously at a median dose of 1.1 mL of a 2.5 mg/mL solution.
• No adverse respiratory or hemodynamic effects were observed in any patient, even in the eight who received multiple doses.

Conclusions:

• Intraoperative ICG fluorescence imaging is a valuable tool for pediatric surgical procedures.
• ICG can be safely administered to pediatric patients as an intraoperative adjunct without significant adverse events.