Related Experiment Video
Updated: Dec 20, 2025

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
Published on: October 17, 2025
Treatment of Acute Lymphoid Leukemia Refractory to Classic First-Line and Rescue Protocols
Flávia Tobaldini Russo1,2, Maria Cristina Martins de Almeida Macedo1,2, Pedro Amoedo Fernades1,2
1Instituto Brasileiro de Controle do Câncer (IBCC), São Paulo, Brazil.
Abstract:
Acute Lymphoblastic Leukemia is a very aggressive malignant disorder of lymphoid cells in adults, with recurrence (30 to 60% of the cases) after the initial treatment. Until this moment, there is no gold standard therapy for the treatment of adult patients with acute relapsed/refractory lymphoblastic leukemia. In this case report, we describe two cases of relapsed leukemia: one of lymphocytic leukemia B and one of trilineage leukemia, which presented a satisfactory response to treatment with Bortezomib associated with Vincristine, Dexamethasone, and Bendamustine.
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