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Hemoglobinopathies in Iran: An Updated Review
Abolfazl Nasiri1,2, Zohreh Rahimi2,3, Asad Vaisi-Raygani2,4
1Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Summary
Hemoglobinopathies, common genetic blood disorders, show diverse molecular and clinical features in Iran
Area of Science:
- Genetics
- Hematology
- Molecular Biology
Background:
- Hemoglobinopathies represent the most prevalent monogenic disorders globally.
- Iran's unique geography and ethnic diversity contribute to a wide spectrum of hemoglobinopathy variations.
- These disorders encompass structural hemoglobin variants, thalassemias, and hereditary persistence of fetal hemoglobin.
Purpose of the Study:
- To review common structural hemoglobin variants in Iran, detailing their hematological and clinical aspects.
- To discuss the epidemiological burden, types, complications, molecular defects, and therapeutic strategies for thalassemias in Iran.
Main Methods:
- Literature review of existing studies on hemoglobinopathies in Iran.
- Analysis of molecular genetics and clinical data for common variants.
- Examination of epidemiological data and treatment approaches for thalassemias.
Main Results:
- Significant regional variations in the prevalence and types of structural hemoglobin variants across Iran.
- Detailed characterization of hematological and clinical phenotypes associated with common variants.
- Comprehensive overview of thalassemia burden, including molecular defects and current therapeutic interventions.
Conclusions:
- Iran exhibits a complex landscape of hemoglobinopathies due to its diverse population and geographic location.
- Understanding these variations is crucial for effective genetic counseling, diagnosis, and management.
- Further research into molecular defects and advanced therapies is needed to mitigate the impact of hemoglobinopathies in Iran.
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