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In vitro anti-Leishmanial activity of compounds in current clinical use for unrelated diseases
1Department of Medical Protozoology, London School of Hygiene and Tropical Medicine, Winches Farm Laboratories, St. Albans, Herts, UK.
Drugs Under Experimental and Clinical Research
|January 1, 1988
Abstract:
Drugs in current clinical use were tested for anti-Leishmania activity using an in vitro infected macrophage assay. Out of almost 400 compounds tested, over 100 were active. The most active compounds showed ED50 values below 1 microM concentration. It is concluded that the active compounds should receive testing in the in vivo system. In addition they will act as lead compounds for further synthetic programmes.