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Updated: Dec 20, 2025

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Intramolecular C(sp2)-C (sp2) bond formation between phenanthroline and β-diketone thiosemicarbazones in PtII
Ana C R Gonçalves1, Andressa R Rettondin, Carolina G Oliveira
1Núcleo de Desenvolvimento de Compostos Bioativos (NDCBio), Universidade Federal do Triângulo Mineiro, 38025-440, Uberaba, MG, Brazil. pedro.maia@uftm.edu.br.
Abstract:
[PtCl2(phen)] reacts with thiosemicarbazones derived from β-diketones (H2LR) leading to an intramolecular C-C coupling between phen and the ketone upon formation of tetradentate N,N,N,S chelates [PtII(LRphen)]. The reactions proceed via bidentate coordination of the doubly deprotonated (LR)2- followed by an intra-nucleophilic attack and consecutive C-C bond formation.
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