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Oral Candida Mannan Concentrations Correlate with Symptoms/Signs of Ill Health and the Immune Status
Yusuke Hakoyama1, Shin-Ichi Yamada2, Fumihiro Nishimaki1
1Department of Dentistry and Oral Surgery, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto, 390-8621, Japan.
Background:
A relationship has been proposed between increases in oral Candida concentrations and host immunity. Therefore, the present study was conducted to investigate the relationship between oral Candida mannan concentrations and symptoms/signs of ill health and the immune status and also to examine whether health/the immune status may be evaluated based on oral Candida mannan concentrations.
Patients And Methods:
The health conditions of 25 healthy individuals and 10 cancer patients receiving cytotoxic chemotherapy were assessed using a questionnaire and oral rinse solutions collected on consecutive days. Candida mannan concentrations in oral rinse solutions were measured using a commercial sandwich ELISA kit.
Results:
The use of dentures was identified as a significant independent factor increasing Candida mannan concentrations. In a stratified analysis based on the use of dentures, significantly increased Candida mannan concentrations were detected in healthy volunteers with chills and in cancer patients with slight/moderate fever (37.5-38.4 °C) (multivariate analysis, p < 0.01) who were non-denture users. These symptoms/signs may be associated with (pre-)infection, during which the immune system is activated and needs to function well.
Conclusions:
The present results suggest that oral Candida mannan concentrations are a predictive marker for health/the immune status.
Insights
Oral Candida mannan concentrations may indicate immune status. Higher levels were linked to symptoms of ill health, suggesting it can be a predictive marker for overall health and immune function.
Area of Science:
- Oral microbiology
- Immunology
- Medical diagnostics
Background:
- A link between oral Candida levels and host immunity is suggested.
- Oral Candida mannan concentrations may reflect immune status.
- Investigating oral Candida mannan as a health indicator is warranted.
Purpose of the Study:
- To explore the relationship between oral Candida mannan concentrations and ill health symptoms.
- To assess the correlation between oral Candida mannan levels and immune status.
- To determine if oral Candida mannan concentrations can predict health and immune status.
Main Methods:
- Assessed health of 25 healthy individuals and 10 cancer patients.
- Collected oral rinse solutions over consecutive days.
- Measured Candida mannan concentrations using a commercial sandwich ELISA kit.
Main Results:
- Denture use significantly increased oral Candida mannan concentrations.
- Elevated Candida mannan levels were found in healthy individuals with chills.
- Increased concentrations were observed in cancer patients with mild fever (non-denture users).
Conclusions:
- Oral Candida mannan concentrations show potential as a predictive marker.
- These concentrations may reflect the body's immune status.
- Further research could validate Candida mannan as a diagnostic tool.
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