The decision-making process, experience, and perceptions of preimplantation genetic testing (PGT) users

Area of Science:

• Reproductive Medicine
• Medical Genetics
• Sociology of Health

Background:

• Preimplantation genetic testing (PGT) is a widely adopted technology.
• Limited qualitative data exists on user experiences and motivations for PGT.
• Understanding user perspectives is crucial for improving PGT services.

Purpose of the Study:

• To explore the experiences, concerns, expectations, and attitudes of PGT users.
• To analyze the personal and societal factors influencing PGT decisions.
• To gather in-depth qualitative data on the PGT journey.

Main Methods:

• Semi-structured interviews were conducted with 43 PGT users in Israel.
• Participants had undergone PGT for HLA matching or various genetic disorders.
• Qualitative analysis explored user experiences and decision-making.

Main Results:

• Key motivations for PGT include preventing severe diseases and familial genetic conditions.
• Religious beliefs significantly influenced the acceptance of PGT.
• Users emphasized the need for enhanced emotional support and acknowledgment of potential procedural failures.
• Clinical outcomes reported implantation rates of 38-40% and live birth rates of 27-30%.

Conclusions:

• The study highlights the unique needs of diverse PGT user groups.
• There is a clear need for comprehensive counseling services tailored to PGT users.
• Improving emotional support and addressing potential failures can enhance the PGT experience.