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CD8+GITR+ T cells may negatively regulate T cell overactivation in aplastic anemia

Guixuan Huang1, Yuping Zhang2, Xiaolei Wei3

  • 1Institute of Hematology, School of Medicine, Jinan University, Guangzhou, China.

Immunological Investigations
|May 29, 2020
PubMed
Summary

Aplastic anemia (AA) involves overactive CD8+ T cells. Researchers found fewer CD8+ GITR+ T cells and more CD8+ GITR+ CTLA-4+ T cells in AA patients, suggesting GITR+ T cells may regulate T cell activation.

Keywords:
Aplastic anemiaT cell activationglucocorticoid-induced tumor necrosis factor receptor

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