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Mechanical strong stretchable conductive multi-stimuli-responsive nanocomposite double network hydrogel as biosensor
Yang Chen1, Wenwen Wu1, Junrong Yu1
1State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, China.
Journal of Biomaterials Science. Polymer Edition
|May 29, 2020
Summary
Researchers developed a novel stretchable hydrogel responsive to multiple stimuli like heat, pH, and light. This biocompatible material exhibits exceptional strength and conductivity, making it suitable for advanced biosensors and actuators.
Area of Science:
- Materials Science
- Polymer Chemistry
- Biomedical Engineering
Background:
- Multi-stimuli-responsive hydrogels are gaining attention for advanced applications.
- Developing strong, stretchable, and biocompatible hydrogels remains a challenge.
Purpose of the Study:
- To fabricate a novel carboxymethyl chitosan/graphene oxide/poly(N-isopropylacrylamide) nanocomposite double network hydrogel.
- To investigate its multi-stimuli responsiveness (NIR light, thermal, pH, ionic concentration) and mechanical properties.
- To explore its potential applications in healthcare biosensors and remote actuators.
Main Methods:
- Fabrication via a one-pot in situ free radical polymerization using UV light initiation.
- Utilized N-(3-dimethylaminopropyl)-N-ethylcarbodiimidehydrochloride (EDC) and N,N'-bis(acryloyl)cystamine (BAC) as cross-linkers.
- Characterized mechanical strength, stretchability, conductivity, and stimuli-responsive behaviors.
Main Results:
- Achieved a maximum tensile strength of 1046 kPa at 1286% strain and compressive stress of 2.37 MPa at 90% deformation.
- Demonstrated distinct pH, thermal, and ionic concentration-responsive properties.
- Exhibited good conductive properties suitable for biosensor applications.
- Successfully designed a thermal-/NIR-responsive bilayer hydrogel structure.
Conclusions:
- The developed nanocomposite hydrogel offers superior mechanical strength, stretchability, and multi-stimuli responsiveness.
- It shows significant potential as a biocompatible material for healthcare biosensors.
- The bilayer hydrogel design opens possibilities for remote actuator applications.
