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Long non-coding RNA DNM3OS/miR-204-5p/HIP1 axis modulates oral cancer cell viability and migration

Xiaodan Fang1, Zhangui Tang1, Haixia Zhang2

  • 1Department of Oral and Maxillofacial Surgery, Xiangya Stomatological Hospital, Central South University, Changsha, Hunan, China.

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
|May 29, 2020
PubMed
Abstract

Insights

Long non-coding RNA DNM3OS promotes oral cancer by targeting miR-204-5p and HIP1. Inhibiting DNM3OS or its axis may offer new oral cancer treatments.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Non-coding RNAs are crucial in oral cancer development.
  • Identifying novel therapeutic targets is essential for oral cancer treatment.

Purpose of the Study:

  • To identify long non-coding RNAs (lncRNAs) as potential therapeutic targets in oral cancer.
  • To elucidate the underlying molecular mechanisms of identified lncRNAs in oral cancer.

Main Methods:

  • Microarray profiling and RNA-sequencing identified lncRNA DNM3OS.
  • DNM3OS knockdown and miRNA overexpression were performed in oral cancer cell lines.
  • Targeted mRNA and miRNA interactions were verified experimentally.

Main Results:

  • DNM3OS was upregulated in oral cancer tissues and cells, promoting cell viability and migration.
  • DNM3OS targets miR-204-5p, which in turn targets HIP1, inhibiting oral cancer progression.
  • A negative correlation was observed between miR-204-5p and DNM3OS/HIP1, while DNM3OS and HIP1 were positively correlated.

Conclusions:

  • The lncRNA DNM3OS, miR-204-5p, and HIP1 form a regulatory axis.
  • This axis significantly modulates oral cancer cell viability and migration.
  • The DNM3OS/miR-204-5p/HIP1 axis represents a potential therapeutic target for oral cancer.
Keywords:
HIP1lncRNA DNM3OSmiR-204-5poral cancer

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