Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules01:18

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

122
Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
122
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

329
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
329
In Vitro Drug Dissolution: Compendial Testing Models II01:09

In Vitro Drug Dissolution: Compendial Testing Models II

151
Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients,...
151

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reusable gelatin-based inks for 3D printing of veterinary gabapentin tablets: a sustainable approach.

Frontiers in veterinary science·2026
Same author

Viva la pharmacie - Spotlight on pharmaceutical manufacturing science.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2026
Same author

Empowering the pharmaceutical workforce for the digital future.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2026
Same author

Early prediction of tablet defects during pan coating.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2025
Same author

Evaluation of the quality of the fixed-dose triple combination dispersible tablet for HIV-positive paediatric population after the continuous direct compression and batch manufacturing techniques.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2025
Same author

Raman spectroscopy reveals characteristics of sugar excipients in freeze-drying of nanofibrillated cellulose.

International journal of pharmaceutics·2025

Related Experiment Video

Updated: Dec 20, 2025

Fragmenting Bulk Hydrogels and Processing into Granular Hydrogels for Biomedical Applications
10:18

Fragmenting Bulk Hydrogels and Processing into Granular Hydrogels for Biomedical Applications

Published on: May 17, 2022

6.4K

Converting a batch based high-shear granulation process to a continuous dry granulation process; a demonstration with

Krista Taipale-Kovalainen1, Jarkko Ketolainen1, Ossi Korhonen1

  • 1School of Pharmacy, Promis Centre, University of Eastern Finland, Kuopio, Finland.

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
|May 29, 2020
PubMed
Summary

Converting batch high-shear wet granulation (HSWG) to continuous roller compaction (RC) is feasible with minimal formulation changes. Lubricant feeding location significantly impacts final tablet quality in continuous manufacturing (CM).

Keywords:
Batch processContinuous manufacturingHigh-Shear wet granulationKetoprofen tabletsProcess conversionRoller compaction

More Related Videos

Preparation Of Gushukang GSK Granules for In Vivo and In Vitro Experiments
06:16

Preparation Of Gushukang GSK Granules for In Vivo and In Vitro Experiments

Published on: May 9, 2019

8.0K
Gelatin Methacryloyl Granular Hydrogel Scaffolds: High-throughput Microgel Fabrication, Lyophilization, Chemical Assembly, and 3D Bioprinting
10:36

Gelatin Methacryloyl Granular Hydrogel Scaffolds: High-throughput Microgel Fabrication, Lyophilization, Chemical Assembly, and 3D Bioprinting

Published on: December 9, 2022

7.7K

Related Experiment Videos

Last Updated: Dec 20, 2025

Fragmenting Bulk Hydrogels and Processing into Granular Hydrogels for Biomedical Applications
10:18

Fragmenting Bulk Hydrogels and Processing into Granular Hydrogels for Biomedical Applications

Published on: May 17, 2022

6.4K
Preparation Of Gushukang GSK Granules for In Vivo and In Vitro Experiments
06:16

Preparation Of Gushukang GSK Granules for In Vivo and In Vitro Experiments

Published on: May 9, 2019

8.0K
Gelatin Methacryloyl Granular Hydrogel Scaffolds: High-throughput Microgel Fabrication, Lyophilization, Chemical Assembly, and 3D Bioprinting
10:36

Gelatin Methacryloyl Granular Hydrogel Scaffolds: High-throughput Microgel Fabrication, Lyophilization, Chemical Assembly, and 3D Bioprinting

Published on: December 9, 2022

7.7K

Area of Science:

  • Pharmaceutical Manufacturing
  • Chemical Engineering
  • Materials Science

Background:

  • Transitioning pharmaceutical tablet production from batch to continuous manufacturing offers significant advantages.
  • Roller compaction (RC) presents a simpler, inherently continuous alternative to traditional batch processes like wet granulation (WG).
  • Process conversion often necessitates formulation optimization, which this study aimed to minimize.

Purpose of the Study:

  • To investigate the feasibility of converting batch high-shear wet granulation (HSWG) to continuous roller compaction (RC) with minimal formulation changes.
  • To evaluate the impact of different lubricant feeding locations and production rates on the continuous manufacturing process.
  • To identify potential over-lubrication issues and ensure final product quality meets established standards.

Main Methods:

  • Batch HSWG process was converted to continuous RC manufacturing.
  • Investigated three distinct lubricant feeding locations and two production rate levels.
  • Assessed lubricant effects on compacted ribbons and final tablet properties.

Main Results:

  • Successful conversion from batch HSWG to continuous RC was achieved with minimal formulation adjustments.
  • No over-lubrication was observed across the tested configurations.
  • The location of lubricant feeding demonstrably influenced the quality attributes of the final tablets.

Conclusions:

  • Continuous roller compaction is a viable alternative for tablet manufacturing, enabling a shift from batch processes.
  • Careful consideration of lubricant feeding strategies is crucial for optimizing continuous manufacturing processes.
  • Enhanced product and process understanding facilitates flexible and effective transitions to continuous manufacturing (CM).