Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

758
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
758
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

825
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
825
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

554
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
554
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

818
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
818
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

368
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
368
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

689
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
689

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predicting need for step-up approach and recurrence in endoscopic management of anastomotic strictures after esophagectomy: results from a 10-year multicenter retrospective study.

Surgical endoscopy·2026
Same author

Endoscopic septotomy with argon plasma coagulation (ES-APC) for the management of refractory postbariatric surgery fistulas and leaks (with video): results from a tertiary referral center.

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery·2026
Same author

Submucosal Injection-Guided Septotomy (SING) for the Treatment of Zenker's Diverticulum: A Multicenter Study of Over 100 Procedures (With Video).

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society·2026
Same author

Endoscopic Management of Post-Bariatric Surgery Complications: Diagnostic Work-Up and Innovative Approaches for Leak, Fistula, and Stricture Management.

Diagnostics (Basel, Switzerland)·2026
Same author

Artificial intelligence in advanced endoscopic imaging: transforming optical diagnosis in gastroenterology.

Frontiers in medicine·2026
Same author

Clinical, Radiological, and Endoscopic Features of Pancreatic Pseudocyst and Walled-Off Necrosis: How to Diagnose and How to Drain Them.

Journal of clinical medicine·2025

Related Experiment Video

Updated: Dec 20, 2025

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

7.5K

Genetics and epigenetics of IBD.

Vito Annese1

  • 1Head of Gastroenterology and Medical Director, Valiant Clinic, Dubai, United Arab Emirates; CBP American Hospital, Dubai, United Arab Emirates; Aggregate Professor United Arabian Emirates University, College of Medicine & Health Science, Al Ain, United Arab Emirates.

Pharmacological Research
|May 29, 2020
PubMed
Summary

Genetic and epigenetic studies reveal new inflammatory pathways for inflammatory bowel diseases (IBD). While not yet changing management, future discoveries promise personalized IBD treatments and better prediction of disease outcomes.

Keywords:
Crohn's disease (CD)EpigeneticGeneticGenome-wide association study (GWAS)Inflammatory bowel disease (IBD)Ulcerative colitis (UC)

More Related Videos

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
09:08

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies

Published on: June 2, 2021

2.0K
Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
09:44

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

Published on: October 14, 2025

262

Related Experiment Videos

Last Updated: Dec 20, 2025

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

7.5K
Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
09:08

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies

Published on: June 2, 2021

2.0K
Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
09:44

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

Published on: October 14, 2025

262

Area of Science:

  • Gastroenterology
  • Immunology
  • Genetics

Background:

  • Inflammatory bowel diseases (IBD) are chronic gastrointestinal disorders with unknown causes but a known genetic link.
  • Genetic and epigenetic research has significantly advanced understanding of IBD, revealing new inflammatory pathways and mechanisms.
  • Despite extensive research, genetic markers and environmental factors have not yet altered current IBD management strategies.

Purpose of the Study:

  • To review recent discoveries in IBD genetics and epigenetics.
  • To highlight findings with potential relevance for clinical practice.
  • To explore future possibilities for personalized IBD therapy.

Main Methods:

  • Review of recent genetic and epigenetic studies on IBD.
  • Analysis of novel inflammatory pathways and mechanisms.
  • Discussion of potential therapeutic targets and predictive markers.

Main Results:

  • Unprecedented genetic and epigenetic information has been generated for IBD.
  • New inflammatory pathways and mechanisms of action have been identified.
  • Disease heterogeneity and environmental factors present challenges in identifying genetic markers.

Conclusions:

  • Recent discoveries offer potential for targeted therapies in IBD.
  • Future advancements may enable better prediction of disease course and treatment response.
  • Personalized management strategies for IBD are a promising future direction.