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Related Experiment Video

Updated: Dec 20, 2025

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

Perfluoroalkyl substances cause Leydig cell dysfunction as endocrine disruptors.

Qiqi Zhu¹, Huitao Li¹, Zina Wen²

¹Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

|May 30, 2020

Summary

Perfluoroalkyl substances (PFASs) disrupt the male endocrine system, potentially causing reproductive issues. This review examines PFAS effects on Leydig cell development and male hormone levels, highlighting risks from gestational and postnatal exposure.

Keywords:

Leydig cells Perfluoroalkyl substances Steroidogenesis Structure-activity relationship of PFASs

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Last Updated: Dec 20, 2025

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Published on: September 28, 2022

Area of Science:

Endocrinology
Toxicology
Reproductive Biology

Background:

Perfluoroalkyl substances (PFASs) are persistent organic pollutants and endocrine disruptors.
PFASs may interfere with the male endocrine system, impacting reproductive tract development and fertility.

Purpose of the Study:

To review Leydig cell development and function in rodents.
To examine the effects of PFAS exposure on Leydig cell development during critical life stages.
To discuss human epidemiological data on PFAS and male sex hormone levels.

Main Methods:

Review of rodent studies on Leydig cell development and PFAS exposure.
Analysis of human epidemiological data on PFAS and hormone levels.
Discussion of structure-activity relationships of PFASs.

Main Results:

PFAS exposure during gestational and postnatal periods affects Leydig cell development.
Evidence suggests a link between PFAS and altered male sex hormone levels in humans.
Structure-activity relationships indicate specific PFAS properties influence Leydig cell steroidogenesis.

Conclusions:

PFASs pose a significant risk to male reproductive health through endocrine disruption.
Further research is needed to fully understand the long-term impacts of PFAS exposure.
Mitigation strategies are crucial to protect male reproductive function from PFAS contamination.