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Determination of clozapine in human serum by capillary gas chromatography
1Institut für Klinische Pharmakologie der Medizinischen Akademie Carl Gustav Carus, Dresden, G.D.R.
Journal of Chromatography
|December 30, 1988
Abstract:
A gas chromatographic method using a fused-silica wide-bore capillary column and a nitrogen-specific detector for the determination of the antipsychotic agent clozapine in human serum is described. This method was found to be suitable for the determination of serum levels down to 1-2 ng/ml. The sensitivity, precision and accuracy of this method are adequate for studies on pharmacokinetics and bioavailability.