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Related Experiment Video

Updated: Dec 20, 2025

Rapid One-step Enzymatic Synthesis and All-aqueous Purification of Trehalose Analogues
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Trehalose for Ocular Surface Health.

Jarmo Laihia1, Kai Kaarniranta2,3

  • 1Finnsusp Ltd., Pääskykalliontie 5, FI-21420 Lieto, Finland.

Biomolecules
|May 30, 2020
PubMed
Summary
This summary is machine-generated.

Trehalose, a natural sugar, shows promise for protecting cells from damage and improving conditions like dry eye. Research highlights its benefits in managing oxidative stress and inflammation, particularly in eye treatments.

Keywords:
animal modelsautophagycytoprotectiondry eye syndromesinflammationmolecular chaperonesoxidative stresspatentsrandomized controlled trialstrehalose

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Area of Science:

  • Biochemistry
  • Ophthalmology
  • Pharmacology

Background:

  • Trehalose is a naturally occurring disaccharide found in many organisms, but not vertebrates.
  • It possesses unique bioprotective properties with growing scientific interest.
  • Its potential therapeutic applications are being explored, especially in ocular health.

Purpose of the Study:

  • To review scientific evidence on trehalose's functions in oxidative stress, protein clearance, and inflammation.
  • To emphasize findings from animal models and clinical trials in ophthalmology.
  • To understand trehalose's benefits for ocular surface disease and dry eye.

Main Methods:

  • Literature review of scientific findings on trehalose.
  • Analysis of data from animal models and human clinical trials.
  • Examination of patent landscape for trehalose in dry eye treatment.

Main Results:

  • Trehalose demonstrates protective effects against oxidative stress.
  • It plays a role in cellular protein clearance mechanisms.
  • Evidence suggests benefits in managing inflammation relevant to ocular surface diseases.

Conclusions:

  • Trehalose exhibits significant potential for therapeutic use, particularly in ophthalmology.
  • Its bioprotective qualities are beneficial for patients with ocular surface disease.
  • Future prospects for trehalose in dry eye treatment are promising.