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A small scanning tunnelling microscope with large scan range for biological studies.

R Emch1, P Descouts, P Niedermann

  • 1Group of Biomedical Applied Physics, University of Geneva, Switzerland.

Journal of Microscopy
|October 1, 1988
PubMed
Summary

A novel scanning tunneling microscope (STM) for biological applications features a parallel scanner for high-resolution imaging in air or liquids. Its compact design and precise piezoelectric constant offer excellent linearity for detailed nanoscale analysis.

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Area of Science:

  • Biophysics
  • Nanotechnology
  • Microscopy

Background:

  • Scanning tunneling microscopy (STM) is a powerful tool for nanoscale imaging.
  • Existing STM systems often have limitations in biological applications, particularly when operating in liquid or air environments.
  • Integrating optical microscopy with STM can enhance sample observation and analysis.

Purpose of the Study:

  • To develop a specialized scanning tunneling microscope (STM) optimized for biological applications.
  • To introduce novel features enhancing usability in air and liquid environments.
  • To characterize the performance and piezoelectric properties of the developed STM system.

Main Methods:

  • Designed and constructed a compact STM with a parallel scanner configuration.

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  • Integrated a high-resolution optical microscope for simultaneous observation.
  • Utilized interferometry and STM measurements to analyze scanner tube piezo-sensitivity.
  • Evaluated scanner linearity using large-scale carbon grid images.

    • Main Results:

    • The STM system exhibits a compact size (10x40 mm) with scan ranges of 5x20 microm (lateral) and 20 microm (vertical).
    • Piezoelectric constant (d13) was measured as -1.71 A/V at low voltages, increasing to -2 A/V at higher voltages.
    • Demonstrated excellent linearity of the scanner tube, confirmed by large-scale imaging.

    Conclusions:

    • The developed STM is well-suited for biological applications due to its design and performance.
    • The parallel scanner configuration facilitates high-resolution optical observation during STM operation.
    • The system's precise piezoelectric properties and linearity ensure reliable nanoscale imaging in diverse environments.