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Updated: Dec 20, 2025

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
Squamous Cell Carcinoma Arising from Sinonasal Inverted Papilloma
D T Ginat1, A Trzcinska2, P Horowitz3
1From the Departments of Radiology, Section of Neuroradiology (D.T.G.) dtg1@uchicago.edu.
Abstract:
Sinonasal inverted papillomas occasionally undergo malignant transformation into squamous cell carcinoma, which can be associated with EGFR mutations. Since biopsy can potentially under-sample the tumor, CT and MRI can provide clues as to the presence of malignant transformation. In particular, this entity tends to appear different from benign inverted papilloma on imaging, including prominent bone erosions, necrosis, low diffusivity in the solid tumor components, and absence of the cerebriform pattern on MRI. The radiology findings, pathology features, and management of squamous cell carcinoma arising from inverted papilloma are described.
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