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Related Experiment Video

Updated: Dec 20, 2025

Detection of Architectural Distortion in Prior Mammograms via Analysis of Oriented Patterns
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No association between night shiftwork and mammographic density.

Sonia El-Zaemey1, Lin Fritschi1, Jane Heyworth2

  • 1School of Public Health, Curtin University, Perth, Western Australia, Australia.

Occupational and Environmental Medicine
|May 30, 2020
PubMed
Summary
This summary is machine-generated.

Night shiftwork is not linked to mammographic density, a key breast cancer risk factor. This study found no association between graveyard shifts or related factors and dense breast tissue in women. This suggests mammographic density may not mediate the shiftwork-breast cancer link.

Keywords:
cancershift work

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Area of Science:

  • Epidemiology
  • Breast Cancer Research
  • Occupational Health

Background:

  • Mammographic density is a significant breast cancer risk factor.
  • Night shiftwork is a suspected, but understudied, contributor to breast cancer risk.
  • Factors like light at night, phase shift, and sleep disruption are associated with night shiftwork.

Purpose of the Study:

  • To investigate the association between night shiftwork and mammographic density.
  • To determine if factors related to night shiftwork influence breast density.
  • To clarify the role of mammographic density in the potential link between shiftwork and breast cancer.

Main Methods:

  • Study included 1821 women from the Breast Cancer Environment and Employment Study (2009-2011).
  • Mammographic density was assessed using Cumulus software, measuring absolute dense area (DA) and percentage dense area (PDA).
  • Linear regression models, adjusted for confounders, were used to analyze associations with night shiftwork factors.

Main Results:

  • No significant association was found between graveyard shiftwork and PDA or DA.
  • Night shiftwork-related factors (light at night, phase shift, sleep disturbance) showed no association with PDA or DA.
  • Statistical analysis revealed no link between shiftwork exposure and measures of mammographic density.

Conclusions:

  • Shiftwork and its associated factors do not appear to be linked to mammographic density.
  • Findings suggest mammographic density is not a mediating factor in the relationship between shiftwork and breast cancer risk.
  • This large-scale study provides robust evidence against an association between shiftwork and breast density.