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Updated: Dec 20, 2025

Mouse Models of Epididymitis Induced by Pathogen-Associated Molecular Patterns

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Published on: December 12, 2025

Orchiepididymitis in a Boy With COVID-19.

Luigi Gagliardi¹, Carlo Bertacca¹, Chiara Centenari¹

¹From the Division of Neonatology and Pediatrics, Ospedale Versilia, Viareggio, AUSL Toscana Nord Ovest, Pisa.

The Pediatric Infectious Disease Journal

|May 30, 2020

Summary

The first reported case of orchiepididymitis in a boy with COVID-19 highlights potential nonrespiratory symptoms. Further research is needed to understand pediatric COVID-19 presentations and testicular involvement by SARS-CoV-2.

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Area of Science:

Pediatric Infectious Diseases
Viral Pathogenesis
Reproductive Health

Background:

The clinical spectrum of Coronavirus disease 2019 (COVID-19) in children remains incompletely characterized.
Understanding nonrespiratory manifestations is crucial for comprehensive pediatric COVID-19 diagnosis and management.
Potential viral tropism for specific organ systems requires further investigation.

Observation:

A case of orchiepididymitis, inflammation of the testicle and epididymis, is presented in a pediatric patient diagnosed with COVID-19.
This represents the initial documented instance of this specific genitourinary complication in a child with SARS-CoV-2 infection.
The presentation suggests a possible direct or indirect pathway for SARS-CoV-2 to affect testicular tissue.

Findings:

The study details the clinical course and diagnostic findings of orchiepididymitis in a boy with COVID-19.
It explores potential mechanisms through which the SARS-CoV-2 virus may cause testicular inflammation.
This case expands the known range of symptoms associated with pediatric COVID-19.

Implications:

This finding necessitates increased awareness among clinicians regarding potential nonrespiratory symptoms in pediatric COVID-19 cases.
Further research into the reproductive health implications of SARS-CoV-2 infection in children is warranted.
The case underscores the importance of considering genitourinary involvement in the differential diagnosis of pediatric illnesses during the pandemic.