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Related Concept Videos

Skin Cancer01:30

Skin Cancer

5.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Cells of the Epidermis01:24

Cells of the Epidermis

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The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
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Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Pigmentation01:19

Pigmentation

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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
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Layers of the Epidermis01:21

Layers of the Epidermis

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The epidermis, the outermost layer of the skin, is composed of several distinct layers. From deep to superficial, the layers of the epidermis are as follows:
Stratum Basale
Stratum basale, also known as the stratum germinativum, is the deepest layer of the epidermis. It is composed of a single layer of actively dividing cells called basal cells or basal keratinocytes. These cells constantly undergo cell division to replenish the upper layers of the epidermis. Additionally, melanocytes, which...
7.4K
Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
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Long-term follow-up of a randomized, double-blind, phase III, multi-centre study to evaluate the safety and efficacy of field-directed photodynamic therapy (PDT) of mild to moderate actinic keratosis using BF-200 ALA versus placebo and the BF-RhodoLED® lamp.

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Related Experiment Video

Updated: Dec 20, 2025

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
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Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

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[Actinic keratosis].

M V Heppt1, T Steeb2, R-M Szeimies3

  • 1Hautklinik - Internistisches Zentrum, Universitätsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Deutschland. Markus.Heppt@uk-erlangen.de.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|May 30, 2020
PubMed
Summary
This summary is machine-generated.

Actinic keratoses (AK), precancerous skin lesions from UV exposure, require early treatment to prevent squamous cell carcinoma. Treatment choice for AK depends on patient factors and available interventions.

Keywords:
5‑FluorouracilIngenol mebutateNon-melanoma skin cancerPhotodynamic therapySquamous cell carcinoma

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Generation and Culturing of Primary Human Keratinocytes from Adult Skin
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Generation and Culturing of Primary Human Keratinocytes from Adult Skin

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Generation and Culturing of Primary Human Keratinocytes from Adult Skin
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Area of Science:

  • Dermatology
  • Oncology
  • Public Health

Background:

  • Actinic keratoses (AK) are common precancerous skin lesions caused by UV radiation, particularly affecting fair-skinned individuals.
  • AK represent a significant disease burden, especially in the elderly population.
  • Progression of AK to invasive squamous cell carcinoma necessitates timely and effective treatment.

Purpose of the Study:

  • To review current treatment guidelines and licensed interventions for actinic keratoses in Germany.
  • To emphasize the importance of patient-centered decision-making in selecting appropriate AK treatments.

Main Methods:

  • Review of licensed lesion- and field-directed interventions for AK.
  • Analysis of efficacy and safety profiles of various treatment options.
  • Consideration of patient-specific factors in treatment selection.

Main Results:

  • Multiple treatment options for AK are available in Germany, varying in efficacy and safety.
  • Patient motivation and expectations are crucial factors in choosing the optimal intervention.
  • A collaborative approach between clinician and patient is recommended for AK management.

Conclusions:

  • Early and consistent treatment of actinic keratoses is crucial to prevent progression to squamous cell carcinoma.
  • Treatment selection for AK should be individualized, considering lesion characteristics and patient preferences.
  • Shared decision-making ensures adherence and optimizes outcomes for actinic keratosis management.