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Microparticles (Exosomes) and Atherosclerosis.

Ya-Ting Chen1,2,3,4, Hao-Xiang Yuan1,2,3,4, Zhi-Jun Ou2,3,4,5

  • 1Division of Cardiac Surgery, Heart Center, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhong Shan Er Road, Guangzhou, Guangdong Province, 510080, People's Republic of China.

Current Atherosclerosis Reports
|May 30, 2020
PubMed
Summary
This summary is machine-generated.

Microparticles and exosomes, types of extracellular vesicles, are implicated in atherosclerosis progression. These vesicles show promise as diagnostic biomarkers and therapeutic targets for cardiovascular disease.

Keywords:
AtherosclerosisExosomesExtracellular vesiclesMicroparticlesMicrovesicles

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Area of Science:

  • Cardiovascular Biology
  • Extracellular Vesicles Research
  • Atherosclerosis Pathophysiology

Background:

  • Microparticles and exosomes are key mediators of intercellular communication.
  • They are released from various cell types through distinct biogenesis pathways.
  • These extracellular vesicles play significant roles in physiological and pathological processes.

Purpose of the Study:

  • To review the role of microparticles and exosomes in atherosclerosis development.
  • To explore the diagnostic potential of these vesicles in atherosclerosis.
  • To assess the therapeutic applications of microparticles and exosomes for atherosclerosis.

Main Methods:

  • Literature review of studies on microparticles, exosomes, and atherosclerosis.
  • Analysis of mechanisms by which extracellular vesicles influence vascular health.
  • Evaluation of current and future clinical applications of microparticles and exosomes.

Main Results:

  • Microparticles and exosomes contribute to endothelial dysfunction, inflammation, and thrombosis.
  • Their protein and noncoding RNA cargo influences atherosclerosis progression.
  • Extracellular vesicles are emerging as critical players in cell-to-cell signaling relevant to atherosclerosis.

Conclusions:

  • Microparticles and exosomes are integral to atherosclerosis pathogenesis.
  • These vesicles hold significant potential as diagnostic biomarkers.
  • Targeting microparticles and exosomes offers promising therapeutic strategies for atherosclerosis.