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Related Concept Videos

Other Nuclides: 31P, 19F, 15N NMR01:16

Other Nuclides: 31P, 19F, 15N NMR

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Many organic, inorganic, and biological molecules contain spin-half nuclei such as nitrogen-15, fluorine-19, and phosphorus-31. As a result, NMR studies of these nuclei have found extensive applications in chemical and biological research.
While fluorine-19 and phosphorous-31 have high natural abundances (100%) and positive gyromagnetic ratios, nitrogen-15 has a low natural abundance and a negative gyromagnetic ratio. However, nitrogen-15 is still preferred over nitrogen-14 (which has a...
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Magnetic Resonance Imaging01:24

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Related Experiment Video

Updated: Dec 20, 2025

Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
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Partially Fluorinated Copolymers as Oxygen Sensitive 19 F MRI Agents.

Nicholas G Taylor1, Sang Hun Chung2, Albert L Kwansa3

  • 1Department of Chemistry, The University of North Carolina at Chapel Hill, 125 South Rd, Chapel Hill, NC, 27599, USA.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|May 30, 2020
PubMed
Summary

New fluorinated copolymers enhance 19F MRI agents for disease diagnosis. These agents quantify tissue oxygenation with high sensitivity at clinical field strengths, improving diagnostic capabilities.

Keywords:
19F MRIamphiphilic copolymerfluorinated monomersoxygen sensingpolyacrylates

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Area of Science:

  • Biomedical Imaging
  • Materials Science
  • Medical Diagnostics

Background:

  • 19F magnetic resonance imaging (MRI) offers non-invasive quantification of tissue oxygenation.
  • Current 19F MRI agents lack sufficient sensitivity at clinically relevant field strengths.
  • Oxygen-sensitive 19F MRI is crucial for disease diagnosis and progression monitoring.

Purpose of the Study:

  • Develop novel, highly sensitive oxygen-sensitive 19F MRI agents.
  • Establish structure-property relationships for fluorinated copolymers.
  • Enable accurate spatiotemporal quantification of tissue oxygenation.

Main Methods:

  • Synthesis of a library of partially fluorinated copolymers from highly fluorinated monomers.
  • Evaluation of copolymer sensitivity and performance at clinically relevant magnetic field strengths.
  • Correlation of material composition with 19F MRI performance and oxygen sensitivity.

Main Results:

  • Developed water-soluble, partially fluorinated copolymers as sensitive 19F MRI agents.
  • Achieved a signal-to-noise ratio surpassing clinical visualization thresholds (220 mm vs. 126 mm 19F).
  • Demonstrated linear T1 response to oxygenation with high sensitivity (240×10^-5 mmHg^-1 s^-1).

Conclusions:

  • Identified structure-property criteria for improved modular, water-soluble 19F MRI agents.
  • Established a platform approach for creating next-generation oxygen-sensitive contrast agents.
  • Advanced the potential of 19F MRI for precise medical imaging and diagnostics.