Spondias mombin L. attenuates ventricular remodelling after myocardial infarction associated with oxidative stress...

Area of Science:

• Cardiology and Pharmacology
• Nutritional Science
• Biochemistry

Background:

• Myocardial infarction (MI) leads to significant cardiac remodelling, affecting heart function.
• Spondias mombin L. (SM), a tropical fruit, possesses potential cardioprotective properties.
• Understanding the impact of SM on post-MI cardiac remodelling is crucial for developing therapeutic strategies.

Purpose of the Study:

• To evaluate the effects of Spondias mombin L. (SM) pulp on cardiac remodelling following myocardial infarction (MI).
• To investigate the influence of SM supplementation on functional, morphological, and biochemical parameters in an MI rat model.

Main Methods:

• Male Wistar rats were subjected to myocardial infarction and treated with different doses of SM (100 mg/kg and 250 mg/kg) or standard chow for 3 months.
• Echocardiography and isolated heart studies were used to assess cardiac function.
• Morphological analysis (fibrosis, hypertrophy) and biochemical assays (oxidative stress, inflammation, energy metabolism) were performed on myocardial tissue.

Main Results:

• SM supplementation did not alter systolic or diastolic function as assessed by echocardiography and isolated heart studies.
• However, SM significantly attenuated cardiac remodelling by reducing fibrosis and hypertrophy.
• SM improved energy metabolism efficiency and decreased lipid hydroperoxide, indicating reduced oxidative stress.
• SM supplementation also decreased the activation of inflammatory pathways post-MI.

Conclusions:

• Spondias mombin L. pulp supplementation effectively attenuates cardiac remodelling after myocardial infarction in rats.
• The cardioprotective effects are associated with improved energy metabolism, reduced oxidative stress, and decreased inflammation.
• Higher doses of SM demonstrated greater efficacy in mitigating adverse cardiac remodelling post-MI.