Related Experiment Video
Updated: Dec 20, 2025

Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors
Published on: February 16, 2024
Fungal Infection: A Rare Cause Of Gastric Perforation
Rohan Habib1, Muhammad Waqas Afzal1, Fahad Ahmed2
1Department of Surgery, Ayub Teaching Hospital, Abbottabad, Pakistan.
Abstract:
Gastric perforation is among one of the common indications for a laparotomy. It can occur as a result of an erosive ulcer, long term usage of NSAIDs and malignancy among other causes. Here we report a case of a 70-year-old man with an invasive fungal infection as a cause of his gastric perforation based on histopathological evidence. Although very rare it should be kept in mind as an etiological factor of upper GI perforation especially in old age patients. To the best of our knowledge no previous data on such an association has been reported in our country.
Insights
Invasive fungal infection caused gastric perforation in a 70-year-old man, a rare but critical diagnosis for upper gastrointestinal perforations in elderly patients. This case highlights the need to consider fungal causes in differential diagnoses.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Pathology
Background:
- Gastric perforation is a frequent surgical emergency often linked to peptic ulcers, NSAID use, or malignancy.
- Laparotomy is a common surgical procedure for managing gastric perforations.
- Identifying the underlying cause is crucial for effective treatment and patient outcomes.
Observation:
- A 70-year-old male presented with gastric perforation.
- Histopathological examination revealed invasive fungal infection as the cause.
- This etiology is uncommon compared to typical causes like ulcers or NSAIDs.
Findings:
- The study documents a rare case of gastric perforation attributed to invasive fungal infection.
- Histopathological evidence confirmed the fungal etiology.
- This represents a novel finding in the country, with no prior reported cases.
Implications:
- Invasive fungal infection should be considered in the differential diagnosis of upper gastrointestinal perforation, particularly in elderly patients.
- Awareness of this rare cause can improve diagnostic accuracy and patient management.
- Further research may be warranted to understand the prevalence and risk factors for fungal-induced gastric perforations.
Related Concept Videos
Esophageal Perforation-I: Introduction
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
Esophageal Perforation-II: Clinical Manifestations and Management
Clinical Manifestations:
Gastritis III: Clinical Manifestations and Management
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Other Disorders of Digestive System
Mucosal Barrier of the Stomach
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
