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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer Vaccines01:30

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
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Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Treatment Resistant Cancers02:56

Treatment Resistant Cancers

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Related Experiment Video

Updated: Dec 20, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

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Facing SARS-CoV-2 outbreak in immunotherapy era.

Fabrizio Citarella1, Marco Russano1, Francesco Pantano1

  • 1Department of Medical Oncology, Campus Bio-Medico University, Via Alvaro del Portillo 200, Rome 00128, Italy.

Future Oncology (London, England)
|May 30, 2020
PubMed
Summary

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes inflammation, while immunotherapy boosts immune responses. This study explores potential interactions between SARS-CoV-2 and cancer immunotherapy, focusing on immune system effects.

Keywords:
COVID-19SARS-CoV-2immune checkpoint inhibitorsimmunotherapyinflammation

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Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
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Area of Science:

  • Immunology
  • Virology
  • Oncology

Background:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic presents a global health crisis.
  • SARS-CoV-2 infection can lead to severe inflammation, particularly in critical cases.
  • Immunotherapy is a standard cancer treatment that enhances the immune system's ability to fight tumors.

Purpose of the Study:

  • To examine the effects of SARS-CoV-2 and common immunotherapy treatments on the immune system.
  • To hypothesize potential mechanisms of interaction between SARS-CoV-2 and immunotherapy.
  • To analyze clinical and therapeutic data related to SARS-CoV-2 and its implications for immunotherapy.

Main Methods:

  • Review of available laboratory, clinical, and therapeutic data.
  • Analysis of immune system responses to SARS-CoV-2 infection.
  • Examination of the impact of established immunotherapy treatments on immune function.

Main Results:

  • Identified shared aspects of viral biology with other coronaviruses.
  • Highlighted the role of intense inflammation in severe SARS-CoV-2 cases.
  • Detailed the mechanisms by which immunotherapy modulates the immune system against cancer.

Conclusions:

  • Potential interactions between SARS-CoV-2 and immunotherapy warrant further investigation.
  • Understanding these interactions is crucial for managing cancer patients undergoing immunotherapy during the pandemic.
  • Further research is needed to elucidate the clinical implications for patient care.