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Updated: Dec 20, 2025

Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles PPAs and Related Biomaterials
Published on: June 25, 2018
Synthesis of paenipeptin C' analogues employing solution-phase CLipPA chemistry
Juliana T W Tong1, Iman Kavianinia2, Scott A Ferguson3
1School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland 1010, New Zealand. m.brimble@auckland.ac.nz and Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, 3 Symonds Street, Auckland, New Zealand.
Abstract:
We herein report the synthesis of analogues of the antimicrobial lipopeptide, paenipeptin C', by installing varying lipid moieties using thiol-ene CLipPA (Cysteine Lipidation on a Peptide or Amino Acid) chemistry. Biological evaluation against both Gram-negative and Gram-positive strains indicated that several analogues possessed potent broad-spectrum antimicrobial activity.

