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Production and Titering of Recombinant Adeno-associated Viral Vectors
Published on: November 27, 2011
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An update on ACE2 amplification and its therapeutic potential
Alonso Marquez1,2, Jan Wysocki1,2, Jay Pandit1,2
1Feinberg Medical School, Northwestern University, Chicago, IL, USA.
Acta Physiologica (Oxford, England)
|May 30, 2020
Summary
Angiotensin-converting enzyme 2 (ACE2) degrades Angiotensin II (Ang II), offering organ protection. Strategies to amplify ACE2 activity, including recombinant proteins and variants, are explored for therapeutic potential.
Area of Science:
- Biochemistry
- Cardiovascular Research
- Virology
Background:
- The renin-angiotensin system (RAS) is implicated in numerous diseases.
- Angiotensin II (Ang II) is a key therapeutic target within the RAS.
- ACE-related carboxypeptidase (ACE2) counterbalances Ang II's effects by degrading it into protective Ang-(1-7).
Purpose of the Study:
- To review strategies for amplifying ACE2 activity.
- To explore the therapeutic potential of enhanced ACE2 function.
- To discuss ACE2's dual role as a RAS enzyme and SARS-CoV-2 receptor.
Main Methods:
- Literature review of ACE2-targeting strategies.
- Analysis of recombinant ACE2 protein applications.
- Evaluation of novel shorter ACE2 variants.
Main Results:
- ACE2 plays a critical role in modulating the RAS.
- ACE2 is the primary receptor for SARS-CoV-2.
- Various approaches exist to enhance ACE2 activity.
Conclusions:
- Amplifying ACE2 activity presents a promising therapeutic avenue.
- Soluble recombinant ACE2 protein and novel variants show potential.
- Understanding ACE2's function is crucial for both disease and viral infection treatment.
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