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Cerebral Venous Sinus Thrombosis Associated with Dutasteride Use
Bo Kyu Choi1, Kyeongyeol Cheon1, Bang Hoon Cho1
1Department of Neurology, Gangnam Severance Hospital, Severance Institute for Vascular and Metabolic Research, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Medical Journal
|May 30, 2020
Summary
Dutasteride, a medication for hair loss and prostate issues, may cause cerebral venous thrombosis (CVT), a rare type of stroke. This case report highlights a potential link between dutasteride use and CVT in a young adult.
Area of Science:
- Neurology
- Pharmacology
Background:
- Cerebral venous thrombosis (CVT) is an uncommon stroke subtype, often affecting young adults.
- Risk factors include prothrombotic conditions, pregnancy, infection, malignancy, and certain drugs.
- Dutasteride, a 5α-reductase inhibitor, treats benign prostate hypertrophy and androgenetic alopecia.
Observation:
- A 25-year-old male presented with headache and diplopia after 9 months of dutasteride use for alopecia.
- Symptoms included bilateral papilledema and confirmed thrombosis in the sigmoid and transverse sinuses via MRI.
- Neurological deficits improved upon dutasteride cessation and anticoagulation therapy.
Findings:
- This case report suggests dutasteride as a potential novel cause of cerebral venous thrombosis.
- The mechanism may involve dutasteride-induced estrogen level elevation, promoting thrombus formation.
Implications:
- Clinicians should consider dutasteride use in the differential diagnosis of CVT in young adults.
- Further research is warranted to elucidate the potential causal link and underlying mechanisms.
- This finding may impact prescribing guidelines for dutasteride, particularly in younger populations.
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